Dong M, Giles WH, Felitti VJ, et al. Insights into causal pathways for ischemic heart disease: adverse childhood experiences study. Circulation. 2004. Relationship between Adverse Childhood Experiences and Ischemic heart disease was stronger than individual psychological risk factors (such as depressed affect and anger) and stronger than traditional cardiac risk factors (smoking, physical inactivity, obesity, diabetes and hypertension).