The Center for Collaborative Study of Trauma, Health Equity, and Neurobiology

Systems Biology

Networks   -   Synchronization    -   Signals

All living systems (insects, animals [humans] and plants) function as a SYSTEM - an intimately connected NETWORK of cells and organ tissue sub-systems that are:
- Self-Regulatory; optimally functioning within homeostatic zone through Sensing and Responding
- continuously communicating-responding within itself via back-and-forth "crosstalk" of SIGNALS
- continuously monitoring its external environment and integrating this information into its Sensing and Responding.
Living systems have multiple complex processes (biochemical, physiological, and behavioral) that are ORGANIZED in distinctive PATTERNS - across an almost infinite range of time scales (from sub-cellular, to cellular, to tissue, to organ system, to whole person, to circadian, to lifespan).
 
These patterns are SYNCHRONIZED across all these time-scales and across the entire living system.
RESOURCES

Tavassoly (2018)  Systems biology primer: the basic methods and approaches  Essays Biochem. Overview of current experimental and computational methods used in systems biologyO

Ma'ayan (2017) Complex Systems Biology.  rsif.royalsocietypublishing.org.  Outline of general design principles of complex systems - particularly in humans.

 

 

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