McEwen (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. CLASSIC Resource. Describes why the brain and sensory organs are key to the response to stress - and why the STRESS RESPONSE is both adaptive and maladaptive. Under chronic complex stress, the brain and body are remodeled - resulting in patterns we diagnose as disease.
Chrousos (2009) Stress and disorders of the stress system. Nature Reviews Endocrinology. Stress occurs when the Brain-Body balance (homeostasis) is threatened. Sustained stress affects thinking (cognition, executive function), reward-fear, wake-sleep, and all parts of the endocrine, GI, cardiac, respiratory, metabolic and immune systems. Excess activation of the stress system can impair development, body composition, and lead to a host of behavioral or physical illness.
Klatzkin (2019) Physiologic response to acute stress and the drive to eat. Appetite. The stress-eating relationship is mediated by the STRESS RESPONSE. Understanding the physiologic mechanisms is critical to prevent and treat obesity.